Journal of Clinical Trials and Regulatory Affairs

Association of a Single Nucleotide Polymorphism of IL-21 Gene with Asthma in a Chinese Han Population

Author(s): Jing Lin and Guangre Xu

Background: Autoimmune abnormalities appear to be major predisposing factors for asthma. Rs12508721 and rs2055979 of interleukin-21 (IL-21) gene polymorphisms have been previously found to be associated with autoimmune diseases. This study aimed to assess the role of IL-21 in asthma in a Chinese Han population. 
Method: A total of 199 independent asthma patients and 249 unrelated healthy controls were recruited for this case-control association study. Two SNPs (rs12508721 and rs2055979) were genotyped by PCR-RFLP. 
Results: The allele T frequency of rs12508721 was significantly higher in asthma patients than in controls (OR=1.58, 95% CI=1.18-2.11, P=0.0021). The effect of dominant model (CC versus CT + TT, OR=.83, 95CI=1.24-2.69, P=0.0021) was observed. Distributions of allele and genotype frequencies of the SNP rs2055979 showed no signi´Čücant differences between asthma patients and controls. 
Conclusion: Our findings suggest that polymorphism of IL-21 gene plays an important role in susceptibility to asthma in a Chinese Han Population.



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