Antitumor Activity of Selenium-Enriched a Platensis Combined With Polyphenols, Vitamin E and SOD
Author(s): Saloua Dimassi, Henri Oréal, Catherine Riva
Platensis, widely used as a nutritional supplement, can accumulate selenium (Se) in a dose and time-dependent manner, a
trace element with potential anticancer effects. In this study, we were interested in the cytotoxic effect of Se either as inorganic or organic
form, in Se-enriched A. platensis, and in association with an antioxidant cocktail (polyphenols (olive oil extracts), vitamin E and superoxide
dismutase) (ULTRASELEM® formulation).
Methods: Different A. platensis enrichment protocols of Se were assessed and the antitumor activity of the different forms of Se or in the
ULTRASELEM® formulation was tested in vitro on a murine epithelial colorectal adenocarcinoma (CT26) cell line.
Results: Single dose Se enrichment protocol provided a more profitable Se-enriched A. platensis than daily Se enrichment. Then Seenriched
A. platensis in ULTRASELEM® induced significant in vitro activity on CT26 cells with 30% of cell growth inhibition with two
ULTRASELEM® capsules (50μg.L-1 Se) and more than 90% inhibition with eight capsules (200μg.L-1 Se) without reaching maximal daily
recommended Se intake.
Conclusion: This ULTRASELEM® formulation represents an original combination of antitumor and antioxidant properties eliciting
promising efficacy on cancer and thus an excellent candidate for therapeutic use in cancer prevention and treatment.
Will be updated soon