Contemporary Chemistry

Anti Prostate Cancer, Anti Oxidant Activity and Cytotoxicity of Some Sudanese Medicinal Plants

Author(s): Montasir Ahmed Elnour, Asaad Khalid, Fatima Penech, Mohamed Ahmed Mesaik

Cancer is a class of diseases characterized by out of control cell growth and behavior; Plants have been used in treating human diseases for thousands of years. Since prehistoric times, shamans or medicine men and women of European, Africa, Asia and the Americas acquired a tremendous knowledge of medicinal plants. This paper is carried out to investigate the prostate cancer, antioxidant and Cytotoxicity activities of some Sudanese medicinal plants. A. Arabica leaves and gum, A. mellifera leaves, C. Cajan leaves T. Foenum graecum L. Seeds. All the plant parts were extracted using 80% methanol. The anticancer activity was examined by using MTT assay against PC3 (prostate cancer) cell lines and determine their antioxidant activities by testing DPPH activity, screened for their cytotoxicity using - (4, 5-Dimethyl thiazole- 2-yl)-2, 5-diphenyl tetrazolium bromide (MTT), filter and kept in dark, prepared freshly. The extract A. Arabica gum and leaves has shown very high activity against-PC3 and the extract C.cajan leaves and T. Foenum graecum L and A. mellifera leaves is shown none active anti- PC3with IC50 values 39.4, 64.9, > 100,> 100and > 100μg/ml respectively. All the extract revealed Cytotoxicity activity against Vero cell line were found of no toxic and the inhibition percentage with (87.3, 71.7, 66.6) (-48.03,-46.2, 3.7) respectively. The extract shown very high activity against DPPH (above 80%) A. mellifera leaves 87.64μg/ml.

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