Gut and Gastroenterology


Complete Response to the Combination of Sorafenib and Bronchial Artery Infusion of Cisplatin for Hepatocellular Carcinoma with Multiple Lung Metastasis

Author(s): Toru Ishikawa, Yuichi Kojima, Saori Endo, Michitaka Imai, Motoi Azumi, Yujiro Nozawa, Tomoe Sano, Akito Iwanaga, Terasu Honma, Toshiaki Yoshida

We herein report a complete response case of hepatocellular carcinoma (HCC) with lung metastasis that was successfully treated with bronchial arterial infusion chemotherapy and sorafenib administration. A 67-year-old male diagnosed with HCC in March 2013 was treated with transcatheter arterial chemoembolization and radiofrequency ablation. Lung metastasis was noted in October 2015. We administered sorafenib and IA-callīŖ¨, a fine powder formulation of cisplatin, via the bronchial arteries. This therapy resulted in the disappearance of the lung metastases. The patient had complete response and remained alive for 4 years more after developing lung metastasis.

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