Author(s): Lindsey B Cundra, Steve M D’Souza MD, Parth J Parekh David A JohnsonThe emerging role of diet in the pathogenesis, as well as for treatment, of disease continues to be an evolving area of research. Prevailing literature suggests that the addition of kiwifruit (Actinidia species) to the diet may benefit cardiovascular health, immunity, and gastrointestinal function. Kiwifruit’s emerging therapeutic value has been implicated in blood pressure management, lipid profile regulation, and glycemic control. Most promising are its implications in digestive health by improving functional gastrointestinal symptoms such as dyspepsia, constipation, and bloating. The synergism of its bioactive constituents such as fiber, vitamin C, phytochemicals, and the enzyme actinidin, likely affect the commensal microbiome to confer these distinctive health benefits, although mechanistic actions need further clarification. Here, we review the proposed mechanistic action of kiwifruit on cardiovascular and gastrointestinal health, although additional clinical studies are needed to further define the role of kiwifruit in promoting health as well as a treatment adjunct for mitigating disease.