The Impact of Melatonin and Carbon Ion Irradiation on Mitochondria of Cancer Cells
Author(s): Mu-Tai Liu, Russel J. Reiter
Mitochondria are bioenergetic and biosynthetic organelles which provide energy, supply building blocks for new cells, and regulate
redox homeostasis, oncogenic signaling, innate immunity and apoptosis. Mitochondria play a crucial role in tumor progression, and targeting
mitochondria and mitochondria associated signaling pathways provides therapeutic opportunities to improve the outcome of cancer patients.
Materials and Methods: A systematic review of the existing literature was conducted using the following search terms: ‘melatonin’,
‘X-ray irradiation’, ‘charged particle irradiation’, ‘carbon ion irradiation’, ‘mitochondria’, ‘apoptosis’ and ‘cancer cells’. The search used
PubMed and spanned the period from January 2000 to April 2018.
Results: The impact of melatonin on mitochondria of cancer cells consisted of ‘Melatonin antiproliferative effects require active
mitochondrial function in embryonal carcinoma cells’, ‘Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria
of cancer cells: An implication of the therapeutic potential’, ‘Melatonin increases human cervical cancer HeLa cell apoptosis induced by
cisplatin via inhibition of JNK/Parkin/mitophagy axis’ and ‘Combination of melatonin and rapamycin therapy for head and neck cancer:
Suppression of AKT/mTOR pathway activation, and promotion of mitophagy and apoptosis via mitochondrial function regulation’. The
impact of carbon ion irradiation on mitochondria of cancer cells consisted of ‘Carbon ion beams induce hepatoma cell death by NADPH
oxidase-mediated mitochondrial damage’, ‘MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family
proteins is essential for heavy ion irradiation-induced glioma cell death’, ‘Fragmentation level determines mitochondrial damage response
and subsequently the fate of cancer cells exposed to carbon ion irradiation’ and ‘Carbon ion beam triggers both caspase-dependent and
caspase-independent pathway of apoptosis in HeLa and status of PARP-1 controls intensity of apoptosis’.
Conclusion: Mitochondria are the promising therapeutic targets for cancer treatments in relation to melatonin and carbon ion irradiation.
Further preclinical and clinical investigations are indispensable in order to develop innovative anticancer agents.
Will be updated soon