Author(s): Dereje Bekele DessieOver 125 million girls and women alive today have been cut in the 29 countries in Africa and the Middle East where FGM/C is concentrated and the prevalence of FGM was 80% in 2000 and only a 5% decrease had been observed in 2005 in Ethiopia. The objective of this study was to assess and identify the prevalence and factors associated with female genital mutilation in Ethiopia using 2016 EDHS. The dependent variable was female genital mutilation constructed from a number of variables on uptake of the various WHO recommended for women circumcision (coded as No= 0 and Yes=1). The study used Descriptive Statistics and Binary logistic regression model to identify the critical determinants of FGM. A Study was conducted on 7822 women age 15-49 of which 65.2% were circumcised. The significant factors of Female genital mutilation are region, religion, and education status, place of residence, wealth index, media exposure, parents’ education level and ethnicity. In the study, wealth index, older age of women and being Muslim were factors significantly associated with increased circumcision risk in Ethiopia. Hence, government, health bureau, Health workers and others should increase the awareness of mothers with no education and need for integrated societal development interventions, such as involving religious leaders in women’s mobilization and interventions, targeted at the high FGM clustered rural areas and regions.